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The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine: A corticotropin-releasing factor (hCRF1) antagonist

✍ Scribed by Paul J. Gilligan; Caryn Baldauf; Anthony Cocuzza; Dennis Chidester; Robert Zaczek; Lawrence W. Fitzgerald; John McElroy; Mark A. Smith; H.-S.L. Shen; Jo Anne Saye; David Christ; George Trainor; David W. Robertson; Paul Hartig


Book ID
108480786
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
172 KB
Volume
8
Category
Article
ISSN
0968-0896

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1,2-Methyl shift in the reaction of 4,7-
✍ Sergey A. Komykhov; Sergey M. Desenko; Alexander S. Kaganovsky; Valery D. Orlov; πŸ“‚ Article πŸ“… 2000 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 115 KB

## Abstract The reaction of the heterocyclic enamine **1** with tosyl azide (**2**) leads to the tosylimino derivative **4** of 1,2,4‐triazolo[1,5‐a]pyrimidine. The extrusion of nitrogen from the primary adduct **3** is followed by a 1,2‐shift of a methyl group. The structure determination of **4**