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The disconnect between phase II and phase III trials of drugs for heart failure

✍ Scribed by Vaduganathan, Muthiah; Greene, Stephen J.; Ambrosy, Andrew P.; Gheorghiade, Mihai; Butler, Javed

Book ID
120498555
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
252 KB
Volume
10
Category
Article
ISSN
1759-5002

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In comparing two treatments under a typical sequential clinical trial setting, a 50-50 randomization design generates reliable data for making efficient inferences about the treatment difference for the benefit of patients in the general population. However, if the treatment difference is large and