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The dilution factor of intravenously injected hemopoietic stem cells

โœ Scribed by Gastone Matioli; Helmut Vogel; Helgard Niewisch

Publisher
John Wiley and Sons
Year
1968
Tongue
English
Weight
443 KB
Volume
72
Category
Article
ISSN
0021-9541

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โœฆ Synopsis

In order to measure the total number of stem cells present in a given preparation, it is necessary to know the fraction of stem cells which settle in the spleen and form macroscopically visible colonies. The intravenous injection does not allow a direct measurement of this fraction. However, its value is established by injecting stem cells directly into the spleen, thus minimizing the dilution of stem cells through the circulation. It has been measured with this procedure, that only 4% of intravenously injected stem cells form spleen colonies.

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