The diffusion process of sodium hyaluronate (Na-Ha) and Na-Ha-n-alkyl derivatives films swelling
✍ Scribed by Aleš Mráček; Karolína Benešová; Antonín Minařík; Pavel Urban; Lubomír Lapčík
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 208 KB
- Volume
- 83A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
The process of diffusion of sodium hyaluronate and its hydrophobically modified alkyl derivatives in water was studied by measuring the kinetics of solid polymer film swelling. The following fundamental thermodynamic parameters of the swelling process were calculated: the apparent diffusion coefficient of swelling by water D~s~ determined at three temperatures (25, 37, and 45°C), the activation enthalpy of diffusion connected with the swelling Δ__H__~D,s~ and the activation enthalpy of the swelling process Δ__H__~s~. The thermodynamic activity of the solvent for the given sodium hyaluronate and its four alkyl derivatives has been expressed through the internal quantity RA~δ,s~, that is expansion work of polymer coil accomplished by the action of the internal pressure. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007