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The differences between high and low-dose administration of VEGF to dopaminergic neurons of in vitro and in vivo Parkinson's disease model

✍ Scribed by Takao Yasuhara; Tetsuro Shingo; Kenichiro Muraoka; Yuan wen ji; Masahiro Kameda; Akira Takeuchi; Akimasa Yano; Shinsaku Nishio; Toshihiro Matsui; Yasuyuki Miyoshi; Hirofumi Hamada; Isao Date


Book ID
113500353
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
402 KB
Volume
1038
Category
Article
ISSN
0006-8993

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Parkinson's disease (PD) is an age-related disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (SN) and corresponding motor deficits. Oxidative stress and mitochondrial dysfunction are implicated in the neurodegenerative process in PD. Although dietary