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The diagnostic usefulness of isocitrate dehydrogenase (ICDH) in the marmoset (Callithrix jacchus)

✍ Scribed by C. W. Davy; M. Fulleylove; J. G. Edmunds; D. A. Eichler; B. Rushton; R. J. Tudor; J. M. Walker

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
510 KB
Volume
9
Category
Article
ISSN
0260-437X

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✦ Synopsis

Marmosets were given either a hepatotoxin, carbon tetrachloride, orally or an i.m. injection of a mytoxin, chlorpromazine. Although muscle damage alone caused small increases in the plasma levels of iactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase and isocitrate dehydrogenase (ICDH), only the isoenzyme analysis of ICDH can differentiate definitely between liver and muscle damage. Only very severe muscle damage can increase the plasma concentration of this enzyme but, in this case, the elevation of plasma creatinine kinase levels helps differentiation. It is recommended that the elevation of ICDH is the most specific indicator of hepatic damage in the marmoset.

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