The development of novel HIV integrase inhibitors and the problem of drug resistance
✍ Scribed by Mark A Wainberg; Thibault Mesplède; Peter K Quashie
- Book ID
- 118157821
- Publisher
- Elsevier
- Year
- 2012
- Tongue
- English
- Weight
- 307 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1879-6257
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract We used genotypic and phylogenetic analysis to determine integrase diversity among subtypes, and studied natural polymorphisms and mutations implicated in resistance to integrase inhibitors (INI) in treatment‐naïve persons (n = 220) and ‐experienced individuals (n = 24). Phylogenetics r
HIV-1 integrase (IN), one of the essential enzymes in HIV infection, has been validated as a target for HIV treatment. While more than 20 drugs have been approved by the FDA to treat HIV/AIDS, only one drug, Raltegravir (1), was approved as an IN inhibitor. The rapid mutation of the virus, which lea