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The development of monoclonal antibodies to the human mitochondrial 60-kd heat-shock protein, and their use in studying the expression of the protein in rheumatoid arthritis

✍ Scribed by Mohammed Sharif; Jennifer G. Worrall; Bhag Singh; Radhey S. Gupta; Peter M. Lydyard; Claude Lambert; John McCulloch; Graham A. Rook

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 745 KB
Volume: 35
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780351205

No coin nor oath required. For personal study only.

✦ Synopsis

To assess the claim that the human 60-kd heat-shock protein (HSP) is highly expressed in the joints of patients with rheumatoid arthritis (RA), but is not readily detected in normal tissues.

Methods. Monoclonal antibodies were raised against the human 60-kd mitochondria1 heat-shock protein (P1 protein; hsp60), and their specificity was established. They were then applied to synovial tissue.

Results. HSP was expressed similarly in normal, osteoarthritic, and RA synovium. Low levels of hsp6O were detected in synovial fluid by immunoprecipitation.

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