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The development of lysosomal apparatus. II. Incorporation, subcellular distribution, and intraparticulate hydrolysis of 131 I-albumin by liver of mice at perinatal stages

✍ Scribed by Francisco Bertini; Luis Mayorga; Mercedes Gonzalez

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 568 KB
Volume: 109
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041090211

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✦ Synopsis

Abstract

Mouse fetuses at 15th and 18th day of gestation, and newborns aging 0, 5, 10, and 15 days were injected i.p. with 131 I‐albumin (RISA). The degree of incorporation by liver and the intraparticulate hydrolysis of RISA in 27,000g × 10 min. particles increased after birth. By this time, changes in subcellular distribution of RISA and marker enzymes were also observed. Following an i.p. injection of India ink, numerous hepatic cells stained with carbon particles were observed at the light microscope from day 5 of life. The results suggest that the lysosomal apparatus acquires full capacity to incorporate colloidal particles and to degrade foreign macromolecules in the first week of life.

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✍ Héctor R. Mazzei; Francisco Bertini 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 526 KB

## Abstract The enzymatic activity of five acid hydrolases: acid phosphatase, arylsulfatase A, deoxyribonuclease, β‐glucuronidase, and cathepsin D, was assayed in fetal (fifteenth and eighteenth days of pregnancy) and neonatal (Days 0, 5, 10, and 15 __post‐partum__) mouse liver. With the exception