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The development of imatinib as a therapeutic agent for chronic myeloid leukemia

✍ Scribed by Deininger, M.

Book ID
124073054
Publisher
American Society of Hematology
Year
2005
Tongue
English
Weight
357 KB
Volume
105
Category
Article
ISSN
0006-4971

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Acute myeloid leukemia developing during
Acute myeloid leukemia developing during imatinib mesylate therapy for chronic myeloid leukemia in the absence of new cytogenetic abnormalities
✍ Attaphol Pawarode; Sheila N.J. Sait; Alain Nganga; Lionel J. Coignet; Maurice Ba πŸ“‚ Article πŸ“… 2007 πŸ› Elsevier Science 🌐 English βš– 171 KB

The BCR/ABL tyrosine kinase inhibitor imatinib mesylate produces a high rate of cytogenetic responses in patients with Philadelphia (Ph)-positive chronic myeloid leukemia (CML), but secondary clonal chromosome abnormalities may develop in Ph-negative cells, and acute myeloid leukemia (AML) has been