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The Development of Human Gene Therapy

✍ Scribed by Nabel, Elizabeth G.


Book ID
109466239
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
115 KB
Volume
5
Category
Article
ISSN
1078-8956

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Gene-directed enzyme prodrug therapy for
✍ Rosetta Martiniello-Wilks; Allison Dane; Dale J. Voeks; Geetha Jeyakumar; Elin M πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 310 KB πŸ‘ 1 views

## Abstract ## Background Gene‐directed enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar