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The Development of Genipin-Crosslinked Poly(caprolactone) (PCL)/Gelatin Nanofibers for Tissue Engineering Applications

✍ Scribed by Min Sup Kim; Indong Jun; Young Min Shin; Wonhee Jang; Sun I. Kim; Heungsoo Shin

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
769 KB
Volume
10
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Composite nanofibers of poly(caprolactone) (PCL) and gelatin crosslinked with genipin are prepared. The contact angles and mechanical properties of crosslinked PCL‐gelatin nanofibers decrease as the gelatin content increases. The proliferation of myoblasts is higher in the crosslinked PCL‐gelatin nanofibers than in the PCL nanofibers, and the formation of myotubes is only observed on the crosslinked PCL‐gelatin nanofibers. The expression level of myogenin, myosin heavy chain, and troponin T genes is increased as the gelatin content is increased. The results suggest that PCL‐gelatin nanofibers crosslinked with genipin can be used as a substrate to modulate proliferation and differentiation of myoblasts, presenting potential applications in muscle tissue engineering.

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