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The development and use of iridium(I) phosphine systems for ortho-directed hydrogen-isotope exchange

✍ Scribed by Rhys Salter

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
286 KB
Volume
53
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Rapid and efficient iridium‐mediated hydrogen‐tritium exchange labeling of pharmaceutical compounds is a key methodology in the life sciences industry. A review of the development and use of iridium(I) phosphine systems for ortho‐directed isotopic exchange is described to provide the reader with a comprehensive introduction to the area and to serve as a starting point for experimental investigators. Examples of useful catalyst systems and their application to different substrates types as well as potential areas for further development are discussed. Copyright © 2010 John Wiley & Sons, Ltd.

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✍ Göran N. Nilsson; William J. Kerr 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 185 KB 👁 1 views

## Abstract The preparation and application of groups of new iridium complexes are described. In particular, iridium complexes possessing phosphine ligands and a bulky __N__‐heterocyclic carbene have been shown to be robust and readily handled species and have been applied in a range of directed hy