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The determination of stereochemistry and reactions of 3-hydroxy, 3-methyl cephalosporins

✍ Scribed by Gerald E. Gutowski; Cecelia M. Daniels; R.D.G. Cooper

Publisher: Elsevier Science
Year: 1971
Tongue: French
Weight: 198 KB
Volume: 12
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)97197-7

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✦ Synopsis

In the preceding communication (l), we reported the facile preparation of a novel class of cephalosporins, 3-hydroxy-3-methyl-cepham derivatives, I, via acid catalyzed ring expansion of penicillin sulfoxides.

This communication describes some additional chemical and spectroscopic properties of these compounds, and thus establishes the 2 configuration at C3 (i.e., 3B-hydroxyl).

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