The determination of platinum in biological tissue by instrumental neutron activation analysis

✍ Scribed by G.W. Haverland; L.I. Wiebe

• Publisher: Elsevier Science
• Year: 1991
• Weight: 200 KB
• Volume: 42
• Category: Article
• ISSN: 0883-2889
• DOI: 10.1016/0883-2889(91)90183-2

✦ Synopsis

Neutron activation analysis was used to determine platinum in the tissues of rats that had received doses of the tumor chemotherapy agent cis-Pt. Two elements causing spectral interference were identified as 47Sc from 46Ca, a natural component of tissue, and tin (117mSn), an element introduced inadvertently during necropsy and sample work-up. A protocol was devised to correct for interference, using emission lines from 47Ca and 113Sn, respectively, with appropriate consideration for relative detector efficiencies, decay times and half-lives.