The determination of fenspiride in human plasma and urine by liquid chromatography with electrochemical or ultraviolet detection

✍ Scribed by C. Sauveur; A. Baune; N. Vergnes; J.Ph. Jeanniot

• Publisher: Elsevier Science
• Year: 1989
• Tongue: English
• Weight: 385 KB
• Volume: 7
• Category: Article
• ISSN: 0731-7085
• DOI: 10.1016/0731-7085(89)80196-7

✦ Synopsis

A selective and sensitive method for the determination of fenspiride in biological fluids is described. The method involves liquid-liquid extraction followed by separation on a reversed-phase column with electrochemical detection for low levels of the drug in plasma (less than or equal to 100 ng ml-1) or UV absorption for higher concentrations in plasma or urine. The method is suitable for pharmacokinetic analyses and drug monitoring studies.