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The determination of dissociation constants and partition coefficients of phenothiazine derivatives

✍ Scribed by Vezin, W

Book ID
122938888
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
484 KB
Volume
3
Category
Article
ISSN
0378-5173

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Determination of dissociation constants
Determination of dissociation constants of sparingly soluble phenothiazine derivatives by second-derivative spectrophotometry
✍ Keisuke Kitamura; Miharu Takenaka; Sachiyo Yoshida; Mariko Ito; Yuriko Nakamura; πŸ“‚ Article πŸ“… 1991 πŸ› Elsevier Science 🌐 English βš– 329 KB

The dissociation constants (pK,) for sparingly soluble phenothiazines (promazine, chlorpromazine, trifluoropromazine) in water were measured by second-derivative spectrophotometry. The intense background signals in the absorption spectra due to the turbidity caused by the precipitation of insoluble