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The detection, accumulation and stabilization of a tetrahedral intermediate in trypsin catalysis

โœ Scribed by Paul Compton; Anthony L. Fink

Book ID
118314762
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
237 KB
Volume
93
Category
Article
ISSN
0006-291X

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Quantum mechanical ab initio (RHF/6-31ุ‰G\*//RHF/3-21G) calculations were used to simulate the formation of the tetrahedral complex intermediate (TC) in serine protease active site by substrates and transition-state analog inhibitors. The enzyme active site was simulated by an assembly of the amino a