The destruction box of human Geminin is critical for proliferation and tumor growth in human colon cancer cells
β Scribed by Yoshida, Kenichi; Oyaizu, Naoki; Dutta, Anindya; Inoue, Ituro
- Book ID
- 110068073
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 530 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Geminin is a potent inhibitor of origin assembly and reβreplication in multicellular eukaryotes and is a negative regulator of DNA replication during the cell cycle. Thus, it was proposed as an inhibitor of cell proliferation and as a potential tumor suppressor gene. However, the protei
## Abstract Human colon cancer cell lines express epidermal growth factor (EGF) mRNA, secrete EGF and may respond to it __via__ the cellβsurface EGF receptor (EGFR). Expression of these molecules in human colon and colon tumor, however, is not clear. Reverse transcriptionβpolymerase chain reaction
Thymidine labelling index (LI) was prospectively assayed in vitro in a series of 128 consecutive patients with breast cancer. The follow-up was longer than 15 years for all patients. The distribution of LI was log normal and patients were subdivided into 3 groups (patients with LI = m f u, lower tha