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The design of efficient and selective routes to pyridyl analogues of 2,3-dihydro-1,4-benzodioxin-6-carbaldehyde

✍ Scribed by Christopher W. Barfoot; Pamela Brown; Steven Dabbs; David T. Davies; Alan J. Hennessy; Timothy J. Miles; Neil D. Pearson

Book ID: 104098118
Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 523 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.07.099

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✦ Synopsis

This Letter describes the synthetic routes to challenging pyridyl analogues of 2,3-dihydro-1,4-benzodioxin-6-carbaldehyde which were key intermediates for our antibacterial medicinal chemistry programme. All routes described started from kojic acid (8) and have been used to give multigram quantities of each aldehyde.

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