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The design and synthesis of simple molecular tethers for binding biomembranes to a gold surface

โœ Scribed by Neville Boden; Richard J. Bushby; Steven Clarkson; Stephen D. Evans; Peter F. Knowles; Andrew Marsh


Book ID
104207966
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
815 KB
Volume
53
Category
Article
ISSN
0040-4020

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โœฆ Synopsis


Molecular tethers have been synthesised for fixing biomembranes to a gold surface. These ~we comprised of a thiol at one end to bind to the gold, a polyethylenoxy chain of defined length (two, six or twelve ethylenoxy units) in the middle and a cholesteryl residue at the other end to insert into the biomembrane.


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โœ Neville Boden; Richard J. Bushby; Quanying Liu; Stephen D. Evans; A.Toby A. Jenk ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 547 KB

N,N'-Disuccinimidyl carbonate has been used to couple diacylglycerophosphatidylethanolamine with bis-o~hydroxypolyethylenoxydisulfide. The resultant thiophospholipids can be used for anchoring biomembranes to gold surfaces.