The design and synthesis of inhibitors of pantothenate synthetase
β Scribed by Tuck, Kellie L.; Saldanha, S. Adrian; Birch, Louise M.; Smith, Alison G.; Abell, Chris
- Book ID
- 111644821
- Publisher
- Royal Society of Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 503 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/B609482A
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Dethiobiotin synthetase (DTBS ; E.C. 6.6.6.6), the penultimate enzyme in the biosynthesis of the essential vitamin biotin, is a new potential target for novel herbicides. Inhibitors were designed based on mechanistic and structural information. The in-vitro activities of these potential inhibitors v
Trypanothione synthetase (TryS) is essential for the survival of the protozoan parasite __Trypanosoma brucei__, which causes human African trypanosomiasis. It is one of only a handful of chemically validated targets for __T. brucei__ in vivo. To identify novel inhibitors of __Tb__TryS we screened ou