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The dependence of racemization in peptide synthesis on the relative configuration of amino acids

✍ Scribed by Anatol Arendt; Aleksander M. Kołodziejczyk; Teresa Sołowska


Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
127 KB
Volume
19
Category
Article
ISSN
0040-4039

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✦ Synopsis


Racemization or epimerization in peptide synthesis was investigated by means of teats and found to depend on the mode of activation, the kind of protecting groups, the constitution of the carboxyl component, and the reac-


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A potential use for phenylisothiocyanate (PITC), the most popular Edman reagent, is presented for analysis of the amino acid sequence and configuration in peptides containing oiL-amino acids. After derivatization with PITC of the A'-terminal amino acid (L-TY~) of an enkephalin analogue, [D-Ala', o-L