Protein kinase Mf (PKMf), a constitutively active, atypical PKC isoform, enhances synaptic strength during the maintenance of long-term potentiation (LTP). Here we examine the mechanism by which PKMf increases synaptic transmission. Postsynaptic perfusion of PKMf during whole-cell recordings of CA1
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The dendritic layer-specific persistent enhancement of synaptic transmission induced by repetitive activation of protein kinase A
β Scribed by Yo Shinoda; Keiko Tominaga-Yoshino; Akihiko Ogura
- Book ID
- 117364183
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 626 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0168-0102
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We have reported that treatment with okadaic acid, a potent protein phosphatase inhibitor, has the ability to enhance the synthesis of the 78-kDa glucose-regulated protein (GRP78). This article reports our investigation of another protein phosphatase inhibitor, calyculin A, demonstrating the signali