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The demonstration of α lactalbumin in human breast carcinomas

✍ Scribed by Rosemary A. Walker

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
407 KB
Volume
129
Category
Article
ISSN
0022-3417

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✦ Synopsis

Alpha lactalbumin, a good marker of functional differentiation, has been demonstrated in 51 of a 100 human breast carcinomas examined using the immunoperoxidase technique. There is no relationship between production of alpha lactalbumin and histological differentiation, and the absence or presence of lymph-node metastases.

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The previously predicted structures of human a-lactalbumin by homology with hen egg white lysozyme by an automatic method, after the alignment stage, are compared to the X-ray determined structure of baboon a-lactalbumin. The root mean square by rotation method (RMSR) deviations for 122 C-a atoms be