✦ LIBER ✦

The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients

✍ Scribed by Shun-Ichi Okada; Yoshihirc Akahane; Hiroshi Suzuki; Hiroaki Okamoto; Shunji Mishiro

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 584 KB
Volume: 16
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840160302

No coin nor oath required. For personal study only.

✦ Synopsis

W e investigated amino acid heterogeneity in the variable regions of the EZINS1 viral protein in interferon-responsive and interferon-nonresponsive patients with chronic hepatitis C virus infection. The study assessed whether any particular heterogeneity pattern(s) could be useful in predicting responsiveness to interferon treatment. The nucleic acid sequences of the hepatitis C virus genome were analyzed from six patients with chronic hepatitis treated with an interferon-@, three of whom did not respond to the therapy and another three who showed remarkable improvement in the serum levels of liver enzymes and hepatitis C virus RNA after 6 mo. The complementary

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