The decline in murine splenic PHA and LPS responsiveness following serial transplantation of young and old bone marrow cells

Minimum requirement of donor cells to re

Minimum requirement of donor cells to reduce the glycolipid storage following bone marrow transplantation in a murine model of Fabry disease

✍ Takayuki Yokoi; Hiroshi Kobayashi; Yohta Shimada; Yoshikatsu Eto; Nobuyuki Ishig 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 229 KB

## Abstract ## Background Fabry disease (FD) is a lysosomal storage disorders characterized by a deficiency of the lysosomal enzyme, α‐galactosidase A. This results in the accumulation of glycolipids, mainly globotriaosylceramide (GL‐3), in the lysosomes of various organs. Although bone marrow tra