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The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

✍ Scribed by Bredesen, Dale E.; Mehlen, Patrick; Rabizadeh, Shahrooz; Snipas, Scott J.; Assa-Munt, Nuria; Salvesen, Guy S.


Book ID
109710240
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
386 KB
Volume
395
Category
Article
ISSN
0028-0836

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## Abstract CXCR2 ligands contribute to chondrocyte hypertrophy and apoptosis, important determinants in cartilage pathophysiology. We unraveled the kinetics of signaling, biochemical, transcriptional, and morphological events triggered by GROΞ± in human osteoarthritic chondrocytes kept in three‐dim