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The Dark Side of the Moon: The PI3K/PTEN/AKT Pathway in Colorectal Carcinoma

✍ Scribed by Silvestris, Nicola; Tommasi, Stefania; Petriella, Daniela; Santini, Daniele; Fistola, Ettore; Russo, Antonio; Numico, Gianmauro; Tonini, Giuseppe; Maiello, Evaristo; Colucci, Giuseppe


Book ID
119985187
Publisher
S. Karger AG
Year
2009
Tongue
English
Weight
201 KB
Volume
77
Category
Article
ISSN
0030-2414

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## Abstract We investigated the status of the PI 3‐kinase/AKT/PTEN signaling pathway in a series of 117 head and neck squamous cell carcinomas (HNSCC) in a search for molecular alterations in genes/proteins with potential prognostic value. For this purpose, __PIK3CA__ and __AKT2__ gene amplificatio