For more than a decade it has been known that the vascular endothelium releases a labile factor involved in the relaxation of smooth muscle when stimulated by a variety of vasodilator substances such as acetylcholine (1,2). The identity of this mediator, known originally as endothelium-derived relax
The dark side of nitric oxide: mediator of cell injury
β Scribed by Sharon P. Andreoli
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 560 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0931-041X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Nitric oxide (NO) and peroxynitrite (ONOO^β^) are potential mediators of the injury and cytotoxicity occurring over time to oligodendrocytes in multiple sclerosis (MS) lesions. Our __in vitro__ results indicate that human adult CNSβderived oligodendrocytes are relatively resistant to NO
In the central nervous system (CNS), nitric oxide (NO) is thought to be involved in a variety of functions including synaptic plasticity, long term potentiation, and neurotoxicity. The aim of the present study was to investigate the expression of nitric oxide synthase (NOS) in the mouse CNS, followi
## Abstract ## Objective Chondrocyte cell death, possibly related to increased production of endogenous nitric oxide (NO), has been observed during the pathogenesis of osteoarthritis and rheumatoid arthritis. The purpose of this study was to investigate the potential role of NO in causing chondroc