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The cyclo-oxygenase-2 inhibitor JTE-522 induces apoptosis in human gastric cancer cells,

Book ID
120866852
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2001
Weight
133 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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Non-steroidal anti-inflammatory drugs (NSAIDs) can induce tumor cells to undergo apoptosis in vitro. They have also shown cancer-preventive activity in vivo. The mechanism of their effects is, however, not well defined. We investigated the mechanism by which a new NSAID, NS398, induces apoptosis in