✦ LIBER ✦
The cyanomethyl group for nitrogen protection and iminium ion generation in ring-enlarging pyrrolidine annulations. A short synthesis of the amaryllidaceae alkaloid d,1-crinine
✍ Scribed by Larry E Overman; E.Jon Jacobsen
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 199 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The preparation of cis-3a-aryl-4-oxo-decahydrocyclohepta[b]pyrroles and cis-3a-aryl-4-oxo-octahydroindoles is facilitated by using a cyanomethyl group to both protect nitrogen and serve as a precursor for a formaldehyde imlnlum ion.
Recent publications from our laboratory have described the efficient forma-