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The CXXC Zn binding motifs of the human papillomavirus type 16 E7 oncoprotein are not required for its in vitro transforming activity in rodent cells

✍ Scribed by Braspenning, Joris; Marchini, Antonio; Albarani, Valentina; Levy, Laura; Ciccolini, Francesca; Cremonesi, Caterina; Ralston, Robert; Gissmann, Lutz; Tommasino, Massimo

Book ID
110061173
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
532 KB
Volume
16
Category
Article
ISSN
0950-9232

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## Abstract The E5 oncoprotein of human papillomavirus type 16 downregulates surface MHC Class I and interacts with the heavy chain of the MHC complex __via__ the first hydrophobic domain, believed to form the first helical transmembrane region (TM1) of E5. TM1 contains 4 equally spaced di‐leucine