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The Curtin–Hammett principle in action: 1-amino-3H-isoindole in cycloaddition reactions

✍ Scribed by Igor V. Levkov; Oleksandr V. Turov; Oleg V. Shishkin; Svetlana V. Shishkina; Zoia V. Voitenko


Book ID
108283178
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
254 KB
Volume
66
Category
Article
ISSN
0040-4020

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70 h, H Br 1 37 % S J 100'. 17 h. 2. (Ph)3P=CHCOOEt, CH~CII. r.t., 29 % overall yield ' 'OOE~ quant. 4 racemic mixture, cisltmns 70:30 However, this protocol was limited by several drawbacks in its original version; e.g., when using 2-allylpiperidine in the one-pot ring opening, the cyclized produc