The CSIC Reaction on Substrates Derived From Aldehydes

✍ Scribed by José L Marco; Simon T Ingate; Carlos Jaime; Ivan Beá

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 299 KB
• Volume: 56
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(00)00124-1

✦ Synopsis

The Carbanion-mediated Sulfonate (Sulfonamide) Intramolecular Cyclization reaction (CSIC reaction) on conveniently functionalized cyanoalkylsulfonates and cyanoalkylsulfonamides derived from aldehydes is possible and gives the new heterocyclic ring systems 5-alkyl-4-amino-5H-1,2-oxathiole 2,2-dioxide and 3-alkyl-5H-4-amino-5-cyano-5H-2,3-dihydroisothiazole 1,1-dioxide in good yield.