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The crystal structures of the synthetic C-terminal octa- and dodecapeptides of trichovirin

✍ Scribed by Renate Geßmann; Panaiotis Benos; Hans Brückner; Michael Kokkinidis

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
187 KB
Volume
5
Category
Article
ISSN
1075-2617

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✦ Synopsis

The structures of two synthetic peptides with sequences corresponding to the C-terminal region of the naturally occurring 14-residue peptaibol trichovirin have been determined. The crystal structures of 8and 12-residue segments are presented and are compared with the structures of the tetrapeptide and of the 9-residue segment, which have been reported earlier. A comparison between these segments leads to the hypothesis that the three-dimensional structure of trichovirin is to a large extent determined by the properties of a periodically repeating -Aib-Pro-pattern in the sequence of the peptide.

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