Cytosolic low molecular weight phosphotyrosine-phosphatase shows dephosphorylating activity of the band 3 protein. Increased phosphorylation of this protein increases membrane rigidity and resistance to invasion of red blood cells by malarial parasites. This observation may explain the negative asso
✦ LIBER ✦
The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase
✍ Scribed by Su, Xiao-Dong; Taddei, Niccolo'; Stefani, Massimo; Ramponi, Giampietro; Nordlund, Pär
- Book ID
- 109789470
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 739 KB
- Volume
- 370
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/370575a0
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Molecular dynamics simulation of the Michaelis complex, phospho-enzyme intermediate, and the wild-type and C12S mutant have been carried out to examine hydrogen-bonding interactions in the active site of the bovine low molecular weight protein-tyrosine phosphatase (BPTP). It was found that the S γ a