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The crystal structure of a bacterial, bifunctional 5, 10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

✍ Scribed by Betty W. Shen; David H. Dyer; Jie-Yu Huang; Linda D'Ari; Jesse Rabinowitz; Barry L. Stoddard


Book ID
111753646
Publisher
Cold Spring Harbor Laboratory Press
Year
1999
Tongue
English
Weight
307 KB
Volume
8
Category
Article
ISSN
0961-8368

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A bifunctional enzyme that catalyzes the conversion of formyltetrahydrofolate to methylene-tetrahydrofolate (5,10methenyltetrahydrofolate cyclohydrolase and 5,10-methylene tetrahydrofolate dehydrogenase), has been subcloned from a cDNA library, purified to homogeneity, and crystallized. The crystals