Integration and regeneration are currently the fundamental objectives for medical interventions that are utilising materials and or cells to provide therapeutic benefit. These terms can form the basis of exciting research paradigms through logical progression, as both will derive control through understanding cognitive principles and theories. This potential for the subject to move from research into clinical applications may be expedited by a strictly analytical quantitative approach to provide controlled and successful long term interventions that are additionally safe and definable for regulation. There have been significant developments in the approach to interrogating the biological response to implanted materials, which have made full use of the timely and rapid evolution of the microprocessor. The breakdown and quantitative measurement and description of biological processes facilitates the provision of the detail required to unravel the key mechanisms and processes which will be required to be harnessed to integrate with human tissue to provide regeneration. In the future, a systems biology approach may provide significant potential as a research tool for the further development of regenerative medicine theories into clinic.