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The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas

โœ Scribed by Dammann, Reinhard; Takahashi, Takashi; Pfeifer, Gerd P


Book ID
110064745
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
326 KB
Volume
20
Category
Article
ISSN
0950-9232

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Hypermethylation of the CpG island of th
โœ Jung-Hoon Yoon; Reinhard Dammann; Gerd P. Pfeifer ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 260 KB

Homozygous deletion and loss of heterozygosity (LOH) at chromosome 3p21 have been observed in several types of human cancer including lung cancer and breast cancer. In previous work, we cloned and identified the human RAS association domain family 1A gene (RASSF1A) from the lung tumor suppressor loc