The COX-2 inhibitor Celecoxib enhances the sensitivity of KB/VCR oral cancer cell lines to Vincristine by down-regulating P-glycoprotein expression and function

Celecoxib enhanced the sensitivity of ca

Celecoxib enhanced the sensitivity of cancer cells to anticancer drugs by inhibition of the expression of P-glycoprotein through a COX-2-Independent Manner

✍ Wenhong Xia; Tao Zhao; Jinghuan Lv; Shan Xu; Junfeng Shi; Shui Wang; Xiao Han; Y 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 767 KB

## Abstract The P‐glycoprotein (p170, P‐gp) encoded by human __MDR1__ gene functions as a pump to extrude anticancer drugs from cancer cells. Over‐expression of p170 is closely related to primary and induced drug resistance phenotype of tumor cells. Recent studies have demonstrated that expression