𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The course of hepatitis C virus infection after liver transplantation

✍ Scribed by Cyrille Féray; Michelle Gigou; Didier Samuel; Valérie Paradis; Judith Wilber; Marie France David; Mickey Urdea; Michel Reynes; Christian Bréchot; Henri Bismuth

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
700 KB
Volume
20
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

Hepatitis C virus-induced liver disease is becoming a main indication for liver transplantation. Recurrence of hepatitis after transplantation has been reported, but its long-term consequences are unknown. Seventynine patients positive for hepatitis C virus (group 1) and 106 subjects negative for hepatitis C virus antibody (group 2) with a mean follow-up of 4 yr were retrospectively studied by means of serology, nested polymerase chain reaction and branched-DNA technology before and after liver transplantation. The actuarial rates of hepatitis C virus-related acute hepatitis were 72% and 20% at 4 yr in groups 1 and 2, respectively. Progression to chronic active hepatitis occurred in 61% and 36% of the subjects within 3 yr of the onset of recurrent and acquired hepatitis, respectively. No case of acute graft failure and two cases of cirrhosis were related to recurrent or acquired hepatitis C virus liver disease. Hepatitis C virus RNA levels were significantly increased in cases of hepatitis after transplantation. In contrast, the pretransplant hepatitis C virus RNA level was not predictive of recurrence. Our results establish the general persistence of hepatitis C virus infection after liver transplantation, the frequency and the severe course of recurrent liver disease. However, liver transplantation in hepatitis C virus antibody-positive patients still has a good medium-term prognosis.

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