The correlation of cell disruption with homogenizer valve pressure gradient determined by computational fluid dynamics
✍ Scribed by Andrew R. Kleinig; Anton P.J. Middelberg
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 683 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0009-2509
No coin nor oath required. For personal study only.
✦ Synopsis
Numerical investigations of the flow and pressure fields within a homogenizer valve have been conducted using the computational fluid dynamics code, PHOENICS 2.1. Results are obtained for two valve seat designs over a range of valve gaps. The dependence of valve gap on operating pressure is measured experimentally and compares well with numerical predictions. A simple expression that uses the numerical results and allows ready calculation of pressure gradient from homogenizer operating and design conditions is presented. Pressure gradient is shown to be a better independent variable for correlating cell disruption than operating pressure over a wide range of operating and design parameters. Copyright