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The COP9 signalosome-mediated deneddylation is stimulated by caspases during apoptosis

✍ Scribed by Bettina K. J. Hetfeld; Andreas Peth; Xiao-Ming Sun; Peter Henklein; Gerald M. Cohen; Wolfgang Dubiel


Book ID
106349624
Publisher
Springer
Year
2007
Tongue
English
Weight
401 KB
Volume
13
Category
Article
ISSN
1360-8185

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## Abstract Multiple myeloma (MM) is a malignancy characterized by the accumulation of tumoral plasma cells in bone marrow. This disease remains incurable and the development of new therapeutic strategies is urgently required. We have studied the effects of 2 selective estrogen receptor disrupters