The controversial protein-only hypothesis of prion propagation
β Scribed by Soto, Claudio; Castilla, Joaquin
- Book ID
- 109931588
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 541 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1078-8956
- DOI
- 10.1038/nm1069
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Newly made polypeptide chains require the help of molecular chaperones not only to rapidly reach their final three-dimensional forms, but also to unfold and then correctly refold them back to their biologically active form should they misfold. Most prions are an unusual type of protein that can exis
Poly-L-lysine (PLL), a homopolymer of amino acid L-lysine (LL), has been frequently used for drug delivery. Here, we report that PLL is an effective agent to inhibit propagation of prions that cause fatal and incurable neurologic disorders in humans and animals, termed prion diseases. In our recent