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The Controlled Synthesis of Peptides in Aqueous Medium. I. The Use of α-Amino Acid N-Carboxyanhydrides

✍ Scribed by Denkewalter, Robert G.; Schwam, H.; Strachan, R. G.; Beesley, Thomas E.; Veber, Daniel F.; Schoenewaldt, Erwin F.; Barkemeyer, H.; Paleveda, William J.; Jacob, Theodore A.; Hirschmann, Ralph

Book ID
127154619
Publisher
American Chemical Society
Year
1966
Tongue
English
Weight
297 KB
Volume
88
Category
Article
ISSN
0002-7863

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A synthesis of the N-carboxyanhydrides (NCA's) of several a-ammo acids using bis(trichloromethyl)carbonate, I, is reported.The triphosgene is used to supply phosgene in situ in stoichiometric amounts; it is particularly effective for preparing NCA's of amino acids with long, aliphatic side chains.