The control of calcium influx by cytoplasmic calcium in mammalian heart muscle

✍ Scribed by Mark Stephen Kirby; Clive Orchard; Mark Richard Boyett

• Book ID: 104669593
• Publisher: Springer
• Year: 1989
• Tongue: English
• Weight: 361 KB
• Volume: 89
• Category: Article
• ISSN: 0300-8177
• DOI: 10.1007/bf00220761

✦ Synopsis

The role of Ca2+ in the initiation and maintenance of contraction has been extensively studies. Many of these studies have focused on how Ca2+ influx and efflux affect cytoplasmic Ca2+ (Cai) and, therefore, contraction in cardiac muscle. However, it has recently become apparent that Cai itself may play a major role in the control of Ca2+ influx and efflux from cardiac muscle. Here we review current ideas on the mechanisms underlying Ca2+ homeostasis in cardiac muscle, with specific attention to how Cai may control Ca2+ influx, both under normal and pathological conditions.