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The control of Ca2+ homeostasis: role of intracellular rapidly exchanging Ca2+ stores.

✍ Scribed by Antonello Villa; Jacopo Meldolesi

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
512 KB
Volume
18
Category
Article
ISSN
1065-6995

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✦ Synopsis

ABSTRACT

The role of rapidly exchanging intracellular Ca^2+^ stores in the control of Ca^2+^ homeostasis is reviewed. The following issues are discussed: the reasons why such stores exist in eukaryotic cells; the differences between the terminal cisternae of the skeletal muscle sarcoplasmic reticulum, which have direct, physical connection with the T tubules of the plasmalemma, and the Ca^2+^ stores located in the depth of the cytoplasm, which are stimulated by second messengers; the cytological nature (subcompartments of the ER) of the rapidly exchanging Ca^2+^ stores and their functional significance. The conclusions introduce recent developments in which intracellular Ca^2+^ stores have been investigated also by molecular biology techniques.

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