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The contribution of transcription factor IRF1 to the interferon-γ–interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells

✍ Scribed by Kano, Shin-ichi; Sato, Kojiro; Morishita, Yasuyuki; Vollstedt, Sabine; Kim, Sunhwa; Bishop, Keith; Honda, Kenya; Kubo, Masato; Taniguchi, Tadatsugu


Book ID
109923436
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
590 KB
Volume
9
Category
Article
ISSN
1529-2908

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## T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin42 and interferon-y and is inhibited by transforming growth factor+* Institut fur Immunologie, Maim It was observed in vitro and in vivo that both interferon (1FN)y and interleukin (1L)-12 can promote