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The Contribution of Systematic Approaches to Characterizing the Proteins and Functions of the Endoplasmic Reticulum

✍ Scribed by Schuldiner, M.; Weissman, J. S.

Book ID
121838916
Publisher
Cold Spring Harbor Laboratory
Year
2013
Tongue
English
Weight
667 KB
Volume
5
Category
Article
ISSN
1943-0264

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The unfolded protein response (UPR) is an evolutionarily conserved cell signaling pathway that is activated to regulate protein synthesis and restore homeostatic equilibrium when the cell is stressed from increased client protein load or the accumulation of unfolded or malfolded proteins. Once activ